Skip to main content
. Author manuscript; available in PMC: 2016 Sep 27.
Published in final edited form as: J Mol Biol. 2016 Feb 6;428(6):1180–1196. doi: 10.1016/j.jmb.2016.01.031

Fig. 1. Key proteins involved in histone gene expression.

Fig. 1

Known components of U7-dependent complex that cleaves histone pre-mRNA (blue line) at the 3′ end. 5′ end of U7 snRNA (grey line) base pairs with histone pre-mRNA. The U7 snRNA and the heptameric Sm ring together form the core U7 snRNP that upon interacting with FLASH recruits the HCC, giving rise to holo-U7 snRNP. Only four essential subunits of the HCC are shown: symplekin, CPSF100, CPSF73 and CstF64. Numbers in FLASH indicate amino acids that are required for the interaction of FLASH with the HCC, Lsm11 and NPAT. The arrangement of the four polyadenylation subunits in the HCC is hypothetical. The identity of the subunits that interact with FLASH and Lsm11 has not been determined, as indicated by question marks.