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. Author manuscript; available in PMC: 2016 Sep 27.
Published in final edited form as: J Mol Biol. 2016 Feb 6;428(6):1180–1196. doi: 10.1016/j.jmb.2016.01.031

Fig. 8. A possible set of events that occur at the G1/S phase transition, resulting in activation of histone gene expression.

Fig. 8

FLASH and NPAT interact through their C-terminal regions (indicated by the double-headed arrow), forming a repressive complex that prevents each protein from performing its function in histone gene expression. Phosphorylation of NPAT by Cyclin E/CDK2 at the end of the G1 phase disrupts this complex and activates both transcription of histone genes by liberating NPAT and 3′ end processing of histone transcripts by promoting FLASH-dependent assembly of the active U7 snRNP. The Lsm11-binding sites in the N- and C-terminal region of FLASH are indicated with a long and short vertical arrow, respectively.