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. Author manuscript; available in PMC: 2016 Oct 11.
Published in final edited form as: Nat Neurosci. 2016 Apr 11;19(5):697–705. doi: 10.1038/nn.4282

Figure 1. Ryk conditional deletion enhances motor function recovery from spinal cord injury.

Figure 1

(a) Timeline outlining experimental details of bilateral cervical level 5 (C5) dorsal column lesion. (b–c) Generation of Ryk conditional allele. (b) Exons 3–6 were flanked with loxP sites. (c) Western blot of postnatal day 7 motor cortex extract from mice infected at postnatal day 0 with AAV2/1 synapsin Cre. Full-length blot presented in Supplementary Fig. 8. (d–e) Schematic showing the level of the C5 lesion in relation to motor neuron pools for distinct forelimb muscle groups (adapted from McKenna, Prusky, and Whishaw, 200033). (f) Behavioral performance on forelimb reach skilled food-pellet retrieval task shows enhanced recovery after Ryk conditional deletion in bilateral motor cortex (n=25 mice (control), 17 mice (Ryk cKO), from 21 litters, repeated measures ANOVA P=0.0003, F(1,40)=16.0102). Data presented as mean±s.e.m.