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. Author manuscript; available in PMC: 2016 Oct 11.
Published in final edited form as: Nat Neurosci. 2016 Apr 11;19(5):697–705. doi: 10.1038/nn.4282

Figure 6. Cortical map re-organization during recovery from spinal cord injury.

Figure 6

(a) Timeline outlining experimental details of optogenetic mapping with weekly behavioral testing following bilateral C5 dorsal column lesion. (b) Topographic representation of elbow flexor and extensor activation, relative to bregma (*) prior to and 3 days, 4 weeks, and 8 weeks after C5 dorsal column lesion. Data presented as total number of mice responding with evoked movements at each location, lighter color indicates a larger number of mice are responsive at a given location. Each tic mark represents 300μm. (c) Subsequent C3 dorsal column lesion disrupts remodeled circuitry, while subsequent pyradmidotomy eliminates unilateral evoked motor output. Both measured at 3 days after injury.