Table 1.
Clinicopathologic factors and PP2Ac expression in hepatocellular carcinomas (n=537) based on immunohistochemistry.
| Variables | n | PP2Ac-L (n = 201) | PP2Ac-H (n = 336) | P |
|---|---|---|---|---|
| Sex | ||||
| Male | 380 | 136 | 244 | 0.222 |
| Female | 157 | 65 | 92 | |
| Age (y) | ||||
| <50 | 247 | 93 | 154 | 0.922 |
| ≥50 | 290 | 108 | 182 | |
| Serum AFP level (μg/l) | ||||
| <20 | 180 | 71 | 109 | 0.493 |
| ≥20 | 357 | 130 | 227 | |
| Serum HBsAg | ||||
| Positive | 402 | 137 | 265 | 0.006 |
| Negative | 135 | 64 | 71 | |
| Serum HBeAg | ||||
| Positive | 329 | 105 | 224 | 0.001 |
| Negative | 208 | 96 | 111 | |
| Tumor size | ||||
| ≤2 cm | 76 | 37 | 39 | 0.029 |
| >2 cm | 461 | 164 | 297 | |
| Histological grade | ||||
| Well differentiated | 127 | 68 | 59 | <0.001 |
| Moderately differentiated | 315 | 109 | 206 | |
| Poorly differentiated | 95 | 24 | 71 | |
| Liver cirrhosis | ||||
| Absent | 170 | 79 | 91 | 0.003 |
| Present | 367 | 122 | 245 | |
| Tumor capsule | ||||
| Intact | 116 | 48 | 68 | 0.193 |
| Absent or not intact | 421 | 143 | 268 | |
| Vascular invasion | ||||
| Absent | 116 | 50 | 66 | 0.154 |
| Present | 421 | 151 | 270 | |
| Intrahepatic metastasis | ||||
| Absent | 170 | 91 | 79 | <0.001 |
| Present | 367 | 110 | 257 | |
| TNM stage | ||||
| I + II | 115 | 58 | 57 | 0.001 |
| III + IV | 422 | 143 | 279 | |
| P53 | ||||
| − | 250 | 121 | 129 | <0.001 |
| + | 287 | 80 | 207 | |
| HBxAg | ||||
| − | 153 | 70 | 83 | 0.012 |
| + | 384 | 131 | 253 | |
| Early recurrence | ||||
| No | 230 | 101 | 129 | 0.007 |
| Yes | 307 | 100 | 207 |
NOTE: Significant P values are marked in bold.