Figure 2.

Effect of treatments on tumor growth: Chimeric animals were implanted with orthotopic glioma (U251) and treated with vehicle, vatalanib, nintedanib and AMD3100 from day 8-21. (A) Schematic of chimera establishment, U251 tumor cells implantation, drug treatments and in vivo MRI. (B) All animals underwent MRI on day 22 following implantation of tumors. No significant reduction in tumor growth was observed using vatalanib and AMD3100. Surprisingly, Nintedanib treatment resulted in increased tumor growth as observed by MRI and tumor volume data. Quantitative data is expressed in mean ±SD. *P < 0.05.