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Molecular structure and in vitro kinase activities of EBI-907. (A) chemical structure of EBI-907. (B) Inhibitory activity of EBI-907 and Vemurafenib in BRAFV600E kinase assay. (C) Selectivity profile of EBI-907 against human protein kinase superfamily as shown by a KinomeScan dendogram. The figure was generated by using an online Kinome Render program (http://bcb.med.usherbrooke.ca/kinomerenderLig.php). (D) IC50 values of EBI-907 against a panel of top kinases hit by the compound.
