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Effect of BRAF inhibitors on tumor growth in the Colo-205 xenograft mice model. (A) tumor growth curve in mice bearing colo-205 xenograft treated with daily dosing of compounds (p.o, twice a day) for 14 d (B) The relative volume of tumor xenografts at the end of study. (C) The body weight of mice during the course of treatment. Data were expressed as mean ± SE (n = 9 to 12) ***P<0.001 vs. Vehicle; #P<0.05 vs. 0.05.
