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. 2016 Jan 25;17(2):199–207. doi: 10.1080/15384047.2016.1139231

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Figure 8. — (A) acquired resistance of isolated A375 cells to Vemurafenib. (B) resistance of vemurafenib-resistant A375 cell line to EBI-907. (C) Western blot analysis of ERK and AKT phosphorylation in vemurafenib-sensitive or resistant A375 cells. (D) Western blot analysis of ERK phosphorylation in vemurafenib-sensitive or resistant A375 cells treated with EBI-907. GAPDH was used to as a loading control in panel C and D. (E) Relative growth of parental and vemurafenib-resistant A375 cells in the presence of MEK inhibitor EBI-1051. (F) MEK inhibitor EBI-1051 enhanced the sensitivity of vemurafenib-resistant A375 cells to BRAF inhibition. Quantitative data were expressed as mean ± SD (n = 3).