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The PK parameters of EBI-907 in rats and dogs after an oral dose (mean ± SD, n = 4).
| Rats | Dogs | |
|---|---|---|
| Dose (mg/kg) | 5 | 2 |
| Tmax (h) | 3.33 ± 1.15 | 2.0 ± 0.01 |
| Cmax (ng/ml) | 1498 ± 474 | 972 ± 465 |
| AUCall(h*ng/ml) | 14186 ± 3717 | 8906 ± 4119 |
| AUCinf (h*ng/ml) | 14330 ± 3744 | 11239 ± 4657 |
| MRT (h) | 6.71 ± 0.22 | 15.2 ± 2.3 |
| t1/2 (h) | 3.35 ± 0.28 | 11.3 ± 1.8 |
| CL (ml/min/kg) | 6.12 ± 1.77 | 3.45 ± 1.77 |
| Vdss (ml/kg) | 1787 ± 612 | 15.2 ± 2.3 |
