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. Author manuscript; available in PMC: 2017 Apr 10.
Published in final edited form as: J Mol Biol. 2016 Mar 16;428(7):1455–1464. doi: 10.1016/j.jmb.2016.03.003

Figure 2.

Figure 2

aPKC regulation of the cell cycle. A. When aPKC levels are low, p27Xic1 is able to elongate the G1 to S transition by binding to Cdk2, which can lead to differentiation in Xenopus neuroectoderm progenitor cells. B. When aPKC levels are high, p27Xic1 phosphorylation by aPKC blocks p27Xic1 binding of Cdk2, shortening the G1 to S transition to promote proliferation.