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aPKC regulation of Wnt signaling. aPKC is part of the destruction complex, where it can phosphorylate Catenin to prime it for (2) GSK-3 phosphorylation and subsequent proteasomal degradation. aPKC is also able to phosphorylate YAP, leading to proteasomal degradation. Loss of aPKC or Wnt binding leads to disassembly of the destruction complex and activation of Wnt signaling favoring a proliferative state. The fate of aPKC once the destruction complex is inactivated is unknown.
