. Author manuscript; available in PMC: 2016 Oct 11.

Published in final edited form as: Nat Genet. 2016 Apr 11;48(5):544–551. doi: 10.1038/ng.3548

Table 2.

Loss-of-function of L-alanine dehydrogenase (ald) confers increased resistance to D-cycloserine in vitro. The minimum inhibitory concentration (MIC) to D-cycloserine was determined for each strain on Löwenstein–Jensen media. Testing was done in three independent experiments (assays #1–#3) to establish reproducibility. Dashes indicate those strains were not tested during that experiment.

Strain	D-cycloserine MIC (μg/mL)
Strain	Assay #1	Assay #2	Assay #3
wild type M. tuberculosis	15	15	-
Δald	25	30	25
ald-comp	20	20	20
BCG	40	40	60
BCG-ald-comp	40	-	40
M. bovis	-	25	25