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. Author manuscript; available in PMC: 2016 Sep 14.
Published in final edited form as: Nat Genet. 2016 Mar 14;48(5):510–518. doi: 10.1038/ng.3528

Figure 3. Identification of drug targeting genes from a core disease protein-protein interaction network.

Figure 3

We evaluated the potential role of genes in drug discovery by linking genes from a core protein-protein-interaction (PPI) network (Supplementary Figure 9) to drugs using Drugbank (see Methods). All drugs were selected based on evidence from phase I/II/III randomized clinical trials (RCTs) or published animal studies. Nine drug target genes overlap with the genes from the core network. (a) Connections between biological genes from core PPI (red), and drugs (blue) used for treatment of AS, CD, PS, PSC and UC (yellow). (b) Connections between biological genes from core PPI (red), and drugs (blue) used for treatment of other inflammatory disease and traits (yellow).