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. Author manuscript; available in PMC: 2017 May 30.
Published in final edited form as: Stat Med. 2015 Dec 17;35(12):1985–1999. doi: 10.1002/sim.6842

Table 2.

%Bias, coverage and relative efficiency for estimated treatment effect on cost under different PS estimation methods

Correct PS Misspecified PS SL PS

gamma model %bias Coverage MSER %bias Coverage MSER %bias Coverage MSER

naive regression −9.52 0.67 5.81
covariates adjustmt: normal 6.66 0.92 5.18 7.50 0.88 7.80 5.01 0.92 3.85
covariates adjustmt: lognormal −21.98 0.22 1.35 −22.67 0.12 2.04 −22.19 0.72 1.26
covariates adjustmt: gamma 0.30 0.94 2.07 4.13 0.94 3.12 0.30 0.96 1.53
stratification 2.85 0.91 10.54 32.58 0.77 20.65 1.77 0.94 5.94
IPTW 0.76 0.96 14.25 46.71 0.28 21.48 0.62 0.93 8.95
IPTW: normalized −0.36 0.94 1.83 8.88 0.90 2.76 0.21 0.92 1.58
DR: normal 0.61 0.94 1.46 0.75 0.93 1.31 0.30 0.94 1.07
DR: lognormal −0.71 0.94 1.45 8.91 0.89 1.05 0.38 0.96 0.93
DR: gamma 0.29 0.93 1.53 0.19 0.93 0.94 0.09 0.95 0.90
DR: SL in regression model 0.48 0.92 1 (ref) 3.10 0.94 1 (ref) 0.02 0.90 1 (ref)
mixed
naive regression −48.82 0.29 6.70
covariates adjustmt: normal 44.45 0.54 1.74 45.15 0.54 2.27 42.34 0.60 2.21
covariates adjustmt: lognormal −16.81 0.85 2.54 −26.51 0.85 5.09 −19.18 0.83 4.21
covariates adjustmt: gamma 23.84 0.79 1.46 15.84 0.79 1.84 21.56 0.84 1.71
stratification 12.64 0.91 5.49 15.47 0.77 16.84 9.25 0.95 3.57
IPTW 8.57 0.97 9.47 10.57 0.97 23.13 4.23 0.92 6.00
IPTW: normalized −1.00 0.94 1.10 −2.00 0.94 1.88 −0.80 0.92 1.05
DR: normal −1.81 0.96 1.74 −8.07 0.96 1.03 −1.21 0.95 1.06
DR: lognormal −2.00 0.97 3.85 −6.77 0.98 1.86 −1.24 0.96 1.07
DR: gamma −2.07 0.97 1.82 −1.93 0.95 0.97 −0.34 0.95 1.05
DR: SL in regression model −0.18 0.98 1 (ref) −5.72 0.97 1 (ref) −0.02 0.97 1 (ref)