Table 3.
Markers of proliferation and apoptosis in the experimental groups
| Group | n | Cortical PCNA (%) | BrdU + TECs (cells/mm2) | TUNEL + TECs (Field 1) | TUNEL + TECs (Field 4) |
| Control | 9 | 0 ± 0 (0, 0-0) | 0.2 ± 0.0 (0.2, 0-0.2) | 6.9 ± 2.5 (8, 0-11.2) | 2.7 ± 2.1 (0, 0-5.6) |
| PON d 2 C6+ | 6 | 0.24 ± 0.061 | 8.8 ± 2.71 | - | - |
| (0.28, 0.13-0.36) | (8.9, 2.7-15.3) | ||||
| PON d 2 C6- | 5 | 0.21 ± 0.071 | 6.8 ± 3.11 | - | - |
| (0.18, 0.14-0.30) | (6.4, 0.6-13.2) | ||||
| PON d 4 C6+ | 6 | 0.34 ± 0.081 | 4.6 ± 0.81 | - | - |
| (0.30, 0.09-0.48) | (5.2, 3.4-7.4) | ||||
| PON d 4 C6- | 6 | 0.19 ± 0.041 | 3.2 ± 0.51 | - | - |
| (0.18, 0.14-0.30) | (1.2, 1.7-3.7) | ||||
| PON d 8 C6+ | 8 | 0.15 ± 0.051 | 2.4 ± 0.71 | 13.4 ± 3.3 | 10.0 ± 2.61 |
| (0.11, 0.03-0.16) | (3.1, 0-4.1) | (12.8, 5.6-16.8) | (9.6, 5.6-17.6) | ||
| PON d 8 C6- | 9 | 0.09 ± 0.031 | 2.0 ± 0.71 | 11.4 ± 3.7 | 7.8 ± 2.8 |
| (0.08, 0.02-0.11) | (1.2, 0.1-3.7) | (9.6, 0-17.6) | (6.4, 0-16) |
Data are expressed as mean ± SEM (median, Inter-quartile range);
1
P < 0.05 compared to control group; Field 1 was the sub-capsular cortex; Field 4 was the inner cortex/outer medulla. PCNA: Proliferating cell nuclear antigen; TUNEL: Transferase-mediated nick end-labeling; PON: Protein-overload nephropathy; TEC: Tubular epithelial cells.