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Bioactivity of IL-1Ra-nanoparticles as assessed by inhibition of IL-1β activation of NF-κB activity. ANOVA p < 0.0001. #p < 0.001 vs all other groups, &p < 0.001 vs all other groups. No significant difference was found between any of the IL-1Ra nanoparticles and soluble IL1-Ra.
