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Barriers to overcome by the 3G DDSs. (From reference [31]).
| 1. | Delivery of poorly soluble drugs |
| Non-toxic excipients | |
| 2. | Peptide/protein/nucleic acid delivery |
| Control of the initial burst release and subsequent release rate | |
| Non-invasive delivery | |
| In vitro-in vivo correlation | |
| 3. | Targeted drug delivery |
| Tumor targeting in human | |
| Overcoming blood-brain barrier | |
| 4. | Self-regulated drug delivery |
| Functional in the body for extended period of time |
