Table 1.
Characteristics of women diagnosed with colorectal cancer across tumor stromal and epithelial eosinophil scoresa.
| Participant’s characteristics | Stromal eosinophilscore | Epithelial eosinophil score | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 n=80 |
>1 – 2 n=164 |
>2 – 3 n=111 |
>3 n=86 |
P-valuef | 1 n=250 |
>1 – <2 n=114 |
≥2 n=77 |
P-valuef | |
| Age at colorectal cancer diagnosis | |||||||||
| ≤ 71 y | 21.3 | 26.8 | 36.1 | 40.7 | 25.6 | 34.2 | 42.9 | ||
| 72–77 y | 37.5 | 45.7 | 35.1 | 37.3 | 42.4 | 40.4 | 31.2 | ||
| >77 y | 41.3 | 27.4 | 28.8 | 22.1 | 0.02 | 32.0 | 25.4 | 26.0 | 0.05 |
| BMIb | |||||||||
| <25 kg/m2 | 27.5 | 37.2 | 36.0 | 46.5 | 36.8 | 35.1 | 40.3 | ||
| 25–30 kg/m2 | 37.5 | 39.0 | 33.3 | 25.6 | 36.8 | 31.6 | 33.8 | ||
| >30 kg/m2 | 35.0 | 23.8 | 30.6 | 27.9 | 0.13 | 26.4 | 33.3 | 26.0 | 0.65 |
| Smokingc | |||||||||
| Current | 12.7 | 14.7 | 13.6 | 15.7 | 13.8 | 13.1 | 17.3 | ||
| Former | 16.5 | 23.9 | 21.8 | 16.9 | 20.7 | 21.1 | 20.0 | ||
| Never | 70.9 | 61.4 | 64.6 | 67.5 | 0.76 | 65.5 | 65.8 | 62.7 | 0.95 |
| History of diabetesb | |||||||||
| Yes | 13.8 | 12.8 | 17.1 | 17.4 | 0.68 | 21.6 | 15.8 | 16.9 | 0.36 |
| History of hypertensionb | |||||||||
| Yes | 48.8 | 43.9 | 50.5 | 52.3 | 0.57 | 45.6 | 43.9 | 62.3 | 0.02 |
| History of heart diseaseb | |||||||||
| Yes | 25.0 | 15.9 | 24.3 | 14.0 | 0.10 | 21.6 | 15.8 | 16.9 | 0.36 |
| Stage at diagnosis | |||||||||
| In situ or local | 20.0 | 30.5 | 33.3 | 45.4 | 28.6 | 41.2 | 32.4 | ||
| Regional | 48.8 | 46.3 | 35.1 | 32.6 | 46.4 | 29.0 | 41.6 | ||
| Distant | 20.0 | 12.2 | 13.5 | 8.1 | 13.5 | 12.3 | 13.0 | ||
| Unknown | 11.3 | 11.0 | 18.0 | 14.0 | 0.03 | 11.5 | 17.5 | 13.0 | 0.12 |
| Grade | |||||||||
| Well differentiated | 3.8 | 4.9 | 6.3 | 7.0 | 5.2 | 6.1 | 5.2 | ||
| Moderately differentiated | 50.0 | 61.6 | 66.7 | 62.8 | 58.4 | 64.9 | 63.6 | ||
| Poorly differentiated | 41.3 | 29.3 | 23.4 | 24.4 | 31.2 | 24.6 | 28.6 | ||
| Lymphomas/ not stated | 5.0 | 4.3 | 3.6 | 5.8 | 0.37 | 5.2 | 4.4 | 2.6 | 0.84 |
| Colorectal cancer site | |||||||||
| Colon proximal | 63.8 | 60.4 | 52.3 | 43.0 | 56.0 | 53.5 | 58.4 | ||
| Colon distal/rectal | 33.8 | 37.8 | 47.8 | 55.8 | 42.4 | 44.8 | 41.6 | ||
| Unspecified | 2.5 | 1.8 | 0 | 1.2 | 0.04 | 1.6 | 1.7 | 0 | 0.80 |
| Integrated pathway | |||||||||
| Traditional | 33.9 | 33.8 | 37.1 | 50.8 | 35.0 | 44.4 | 39.7 | ||
| Alternate | 6.8 | 13.2 | 7.9 | 15.9 | 9.4 | 14.8 | 12.7 | ||
| Serrated | 32.2 | 25.7 | 28.1 | 17.5 | 26.1 | 22.2 | 30.2 | ||
| Unassigned | 27.1 | 27.2 | 27.0 | 15.9 | 0.18 | 29.6 | 18.5 | 17.5 | 0.20 |
| Surgeryd | |||||||||
| No | 43.8 | 32.9 | 39.6 | 29.1 | 36.8 | 36.8 | 31.2 | ||
| Yes | 56.3 | 67.1 | 60.4 | 70.9 | 0.16 | 63.2 | 63.2 | 68.8 | 0.64 |
| Chemotherapyd | |||||||||
| No | 73.7 | 78.1 | 78.4 | 81.4 | 78.8 | 79.0 | 74.0 | ||
| Yes | 26.3 | 21.9 | 21.6 | 18.6 | 0.70 | 21.2 | 21.1 | 26.0 | 0.65 |
| Radiationd | |||||||||
| No | 96.1 | 97.6 | 95.4 | 97.6 | 96.3 | 96.4 | 98.7 | ||
| Yes | 3.9 | 2.4 | 4.6 | 2.4 | 0.25 | 3.7 | 3.6 | 1.3 | 0.59 |
| Cytotoxic T cells categoriese | |||||||||
| 1 | 24.9 | 10.5 | 10.4 | ||||||
| >1 – 2 | 37.9 | 27.7 | 13.8 | 14.0 | 42.9 | 38.6 | 29.9 | ||
| >2 – 3 | 38.0 | 41.4 | 34.0 | 29.1 | 14.7 | 29.8 | 24.7 | ||
| >3 | 24.1 | 30.9 | 52.3 | 57.0 | 0.0001 | 17.6 | 21.1 | 35.1 | <0.0001 |
a
Epithelial and stromal eosinophil scores were assessed in epithelial and stromal areas of tumor, respectively.
b
Value at the colorectal cancer diagnosis.
c
Value at baseline (in 1986).
d
Initial course of therapy.
e
Cytotoxic T-cells (or CD8+ T cells) scores in epithelium and stroma were cross-tabulated with corresponding eosinophil scores in epithelium and stroma. The categories in stromal cytotoxic T-cells 1 and >1–2 were combined because of a very low frequency of stromal cytotoxic T-cells in category=1.
f
This is based on a chi-square test.