Table 2.

Hazard ratios for all-cause and colorectal cancer-specific death and 95% confidence intervals in relation to stromal eosinophil score^a in the colorectal cancer patients, Iowa Women’s Health Study.

Stromal eosinophil score		1	>1 – 2	>2 – 3	>3	P-trend
All-cause death
Five-year follow-up
No. deaths (n=172)		41	74	34	23
Person-years		254	587	445	358
HR (95% CI)b		Reference	0.83 (0.56–1.21)	0.51 (0.32–1.21)	0.44 (0.26–0.73)	0.0001
HR (95% CI)c		Reference	0.97 (0.65–1.44)	0.68 (0.42–1.08)	0.61 (0.36–1.02)	0.02
HR (95% CI)d		Reference	0.97 (0.65–1.44)	0.77 (0.47–1.25)	0.69 (0.40–1.19)	0.11
Total follow-upe
No. deaths (n=299)		56	123	72	48
Person-years		523	1267	998	892
HR (95% CI)b		Reference	0.99 (0.72–1.36)	0.74 (0.52–1.05)	0.59 (0.40–0.87)	0.0009
HR (95% CI)c		Reference	1.08 (0.78–1.50)	0.88 (0.61–1.27)	0.72 (0.48–1.08)	0.04
HR (95% CI)d		Reference	1.07 (0.77–1.50)	0.95 (0.65–1.38)	0.79 (0.52–1.20)	0.18
Colorectal cancer death
Five-year follow-up
No. deaths (n=121)		30	53	25	13
Person-years		254	587	445	358
HR (95% CI)b		Reference	0.77 (0.49–1.21)	0.49 (0.29–0.84)	0.32 (0.17–0.62)	<.0001
HR (95% CI)c		Reference	0.96 (0.60–1.52)	0.70 (0.41–1.22)	0.48 (0.24–0.93)	0.01
HR (95% CI)d		Reference	0.97 (0.61–1.55)	0.84 (0.47–1.49)	0.57 (0.29–1.15)	0.11
Total follow-upe
No. deaths (n=138)		30	61	29	18
Person-years		523	1267	998	892
HR (95% CI)b		Reference	0.88 (0.57–1.37)	0.56 (0.34–0.94)	0.43 (0.24–0.77)	0.0005
HR (95% CI)c		Reference	1.05 (0.67–1.64)	0.76 (0.45–1.29)	0.61 (0.34–1.12)	0.04
HR (95% CI)d		Reference	1.07 (0.68–1.68)	0.92 (0.53–1.59)	0.75 (0.40–1.41)	0.31

^aStromal eosinophil score was assessed in stromal area of tumor.

^bModel 1: Adjusted for age.

^cModel 2: Model 1 + BMI, smoking status, stage and grade at diagnosis.

^dModel 3: Model 2 + cytotoxic T-cells (also called CD8+) score.

^eTotal follow- up lasted from the date of diagnosis until death or the end of this study in 2011.