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. Author manuscript; available in PMC: 2016 Aug 26.
Published in final edited form as: Mod Pathol. 2016 Feb 26;29(5):516–527. doi: 10.1038/modpathol.2016.42

Table 3.

Hazard ratios for all-cause and colorectal cancer death and 95% confidence intervals in relation to epithelial eosinophil scorea in the colorectal cancer patients, Iowa Women’s Health Study.

Epithelial eosinophil score 1 >1 – <2 ≥2 P-trend
All-cause death
Five-year follow-up
No. deaths (n=172) 108 39 25
Person-years 884 450 309
HR (95% CI)b Reference 0.74 (0.51–1.06) 0.69 (0.44–1.06) 0.04
HR (95% CI)c Reference 0.91 (0.63–1.33) 0.74 (0.48–1.15) 0.18
HR (95% CI)d Reference 0.95 (0.65–1.38) 0.82 (0.52–1.29) 0.40
Total follow-upe
No. deaths (n=299) 180 74 45
Person-years 1899 1039 739
HR (95% CI)b Reference 0.81 (0.61–1.06) 0.68 (0.49–0.95) 0.01
HR (95% CI)c Reference 0.92 (0.69–1.22) 0.74 (0.53–1.03) 0.08
HR (95% CI)d Reference 0.92 (0.69–1.22) 0.79 (0.56–1.12) 0.22
Colorectal cancer death
Five-year follow-up
No. deaths (n=121) 77 30 14
Person-years 884 450 309
HR (95% CI)b Reference 0.78 (0.51–1.19) 0.53 (0.30–0.94) 0.02
HR (95% CI)c Reference 1.03 (0.67–1.58) 0.58 (0.33–1.03) 0.11
HR (95% CI)d Reference 1.08 (0.70–1.67) 0.70 (0.39–1.26) 0.36
Total follow-upe
No. deaths (n=138) 85 33 20
Person-years 1899 1039 739
HR (95% CI)b Reference 0.76 (0.50–1.14) 0.67 (0.41–1.09) 0.07
HR (95% CI)c Reference 0.98 (0.65–1.48) 0.74 (0.45–1.20) 0.27
HR (95% CI)d Reference 1.02 (0.67–1.54) 0.88 (0.53–1.46) 0.69
a

Epithelial eosinophil score was assessed in epithelial area of tumor.

b

Model 1: Adjusted for age.

c

Model 2: Adjusted for age of diagnosis, BMI, smoking status, stage and grade at diagnosis.

d

Model 3: Model 2 + cytotoxic T-cells (also called CD8+) score.

e

Total follow- up lasted from the date of diagnosis through death or the end of this study in 2011.