Figure 3.
TSA suppressed cisplatin-induced increase in proinflammatory cytokine expression. 72hr after cisplatin administration, cytokine levels in plasma, urine and kidney were quantified by ELISA and RT-PCR. IL-6 (A), TNFα (B), MCP-1 (C) levels in plasma. MCP-1 (D) and IL-6 (E) levels in urine expressed as pg/mg of creatinine. F. Quantification of cytokines, adhesion molecule ICAM-1 and heme oxygenase-1 (HO-1) mRNA by real time RT-PCR. *, p<0.01 vs. other groups. #, p<0.05 vs. cisplatin-treated. n=4-6.