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. 2016 Apr 28;6:105. doi: 10.3389/fonc.2016.00105

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Copyright © 2016 Palma, Grande, Luciani, Mlynárik, Guidoni, Viti and Rosi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Sagittal image of a small spheroid with a diameter of about 0.5 mm, inserted in agarose gel. (B) Sagittal image of a spheroid after 10 days in culture. The diameter is about 1.8 mm. It is possible to identify two different regions: a necrotic core and a viable rim. Both images were acquired with an MSME sequence.