Table 3.
Differences between groups at 4 years.a
| Domain | Radical prostatectomy vs. brachytherapy | Radical prostatectomy vs. IMRT | Radical prostatectomy vs. Androgen deprivationb | |||
|---|---|---|---|---|---|---|
|
| ||||||
| Delta (95% CI) | P | Delta (95% CI) | P | Delta (95% CI) | P | |
| Urinary unction | .83 (−1.59, 3.26) | .5 | 1.06 (−1.64, 3.75) | .4 | −1.53 (−6.45, 3.39) | .5 |
| Incontinence | 10.13 (6.27, 13.98) | <.001 | 11.03 (6.70, 15.37) | <0.001 | 7.30 (−1.11, 15.72) | .089 |
| Irritation or obstruction | −6·36 (−8·55, −4·16) | <0·001 | −6·83 (−9·28, −4·38) | <0·001 | −8·30 (−12·17, −4·43) | <0·001 |
| Urinary bother | −.18 (−3.00, 2.63) | .9 | 1.17 (−1.96, 4.31) | .5 | −1.82 (−7.61, 3.96) | .5 |
| Bowel function | −1.08 (−2.46, .31) | .13 | −1.30 (−2.81, .20) | .090 | −.00 (−2.52, 2.52) | 1 |
| Pain or constipation | .89 (−1.15, 2.92) | .4 | 1.48 (−.92, 3.87) | .2 | 2.44 (−1.95, 6.82) | .3 |
| Diarrhea or frequency | −1.26 (−3.08, .56) | .2 | −0·78 (−2·83, 1·28) | .5 | 1.11 (−2.36, 4.59) | .5 |
| Rectal bleeding | −1.39 (−3.51, .73) | .2 | −4.80 (−7.59, −2.01) | .001 | −3.97 (−7.92, −.01) | .049 |
| Bowel bother | −1.97 (−4.58, .64) | .14 | −2.65 (−5.52, .22) | .071 | −3.02 (−7.32, 1.28) | .2 |
| Sexual function | 14.29 (8.57, 20.01) | <.001 | 10.55 (3.78, 17.33) | .002 | 11.30 (−0.55, 23.15) | .061 |
| Sexual desire | 10.30 (5.61, 14.99) | <.001 | 4.27 (−1.37, 9.90) | .14 | 5.89 (−3.95, 15.73) | .2 |
| Erectile unction | 16.51 (9.43, 23.60) | <.001 | 14.99 (6.75, 23.23) | <.001 | 15.51 (1.06, 29.95) | .035 |
| Sexual bother | 8.40 (3.50, 13.31) | .001 | 7.29 (1.89, 12.68) | .008 | 8.35 (−1.48, 18.19) | .10 |
| Intercourse bother | 7.44 (2.48, 12.41) | 003 | 6.53 (1.19, 11.88) | .017 | 8.76 (−1.02, 18.55) | .079 |
| Intercourse satisfaction | 11.69 (4.10, 19.28) | .003 | 10.08 (1.21, 18.95) | .026 | 10.59 (−4.87, 26.04) | .2 |
Abbreviations: CI = confidence interval, IMRT = intensity-modulated radiotherapy.
a
Difference between means (delta) for scores at 48 months in each domain and subdomain for the treatments specified, with 95% confidence intervals in parentheses. Radical prostatectomy (open or laparoscopic) is the reference group in all comparisons. A positive score means better function in radiotherapy compared with surgery.
b
The androgen-deprivation group includes radiotherapy patients (external beam or brachytherapy) who also received adjuvant or neoadjuvant hormones of any duration. Patients undergoing radiotherapy plus hormonal therapy are thus represented in both columns.