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. 2016 Apr 28;6:24863. doi: 10.1038/srep24863

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Copyright © 2016, Macmillan Publishers Limited

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(a) Circadian clock system (CRY: cryptochrome proteins; CLO: CLOCK; CYC: CYCLE; PER: PERIOD; TIM: TIMELESS). (b) Domain diagram of CLOCK, CYCLE, PERIOD, and TIMELESS. Positions that are conserved within but differ between species are marked by pink dots on blue stems. (c,d) Map of interspecific mutations on the spatial structure template (PDB id: 4F3L) of the CLOCK/CYCLE complex. The mutations are marked by magenta dots and the approximate position of disordered loops is shown as black beads on threads. The magenta star in (c) indicates the position of an inserted domain rich in interspecific mutations that is not present in the structural template. (e) Map of interspecific mutations on the spatial structure template (PDB id: 4F3L) of the protein PERIOD (PDB id: 3RTY_A).