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. 2016 Apr 28;6:24844. doi: 10.1038/srep24844

Figure 4. Effects of FSK on the intracellular calcium ion concentration of ICCs-DM.

Figure 4

(A) Every ten pictures were chosen to represent the process of instantaneous [Ca2+]i changes in the ICCs-DM after treatment with FSK. (B) The real-time relative fluorescence intensities (RFI, F1/F0) are depicted as continuous plots. FSK at a concentration of 50 μmol/L increases the intracellular calcium concentration in both NC and DCP (E) n = 10, independent-sample t-test, ***P < 0.001) rat ICCs-DM, and the increasing effects of FSK on calcium concentration in NC rat ICCs-DM was higher than that in the DCP rat ICCs-DM. (C,D) Showed the representative detrusor tension recording of NC and DCP rat. ZD7288 decreased the detrusor contraction amplitudes in both NC and DCP rat, but had a higher sensitivity on NC rat detrusor strips (F), n = 10, independent-sample t-test, ***P < 0.001).