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. 2016 Apr 25;7:11386. doi: 10.1038/ncomms11386

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The Cl⁻/HCO₃⁻ exchange activity was measured by recording pH_i as detailed in Methods. A clone of HEK 293 cells that exhibited minimal intrinsic anion (Cl⁻/HCO₃⁻) exchange activity (a) was transfected with the indicated plasmids (b–d) and then anion exchange activity was analysed. The quantitation of multiple experiments is depicted in e. Blockade of ER-to-Golgi trafficking by Arf1-Q71L significantly increased Cl⁻/HCO₃⁻ exchange activity in cells expressing H723R-pendrin. ^**P<0.01 by unpaired Student's t-test, the number of replicates (n) is presented in each lane.