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. 2016 Apr 28;6:25145. doi: 10.1038/srep25145

Figure 2. Effect of ondansetron on energy balance of rats fed low protein diets.

Figure 2

Energy intake (a–d) and energy expenditure (EE; (e–h) of obesity-prone rats fed either a control (15% protein; 15P), moderately low protein (10% protein; 10P), very low protein (5% protein; 5P) or protein-free (0% protein; 0P) isocaloric diet with injections of saline or ondansetron (1.0 mg/kg; IP). The analyses of data from the first 9 hours of dark period revealed that there were significant fixed effects of dietary treatment (P < 0.001), drug (P = 0.019) and time (P < 0.001) and interactions of dietary treatment × time (P < 0.001) and drug × time (P = 0.046) for calorie intake. Similarly, there were significant effects of time and dietary treatment (P < 0.001) and interaction of dietary treatment × time (P < 0.001) for energy expenditure. Values are mean ± SEM, n = 8. *P < 0.05 saline vs ondansetron.