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. 2016 Apr 25;7:11412. doi: 10.1038/ncomms11412

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(a) Primary sequence of human IAPP. Wild-type IAPP is C-terminally amidated and has an intramolecular disulfide bond between residues 2 and 7. (b) Chemical structure of ADM-116. (c) Three-dimensional stick (top) and sphere (bottom) model of ADM-116. (d) Pentaquinoline, ADM-|116, in which ADM-116 is extended one residue from the N terminus. Arrows in a,b and d indicate surface-exposed functional moieties. Structures in b and d adapted from a longer oligoquinoline⁴⁷. (e) Chemical structures of other molecules used in this study.