Figure 2. Gene silencing efficacies of the surface-engineered dendrimers in the prepared library.

Relative luciferase activities (normalized to controls) of the 301 materials are screened on HeLa-luc cells. 50 nM siLuc is used for each transfection and the material to siLuc weight ratio ranges from 1 to 20. The gene silencing experiments continue for 24 h. About 7.31% of the materials in the library induced >50% gene knockdown efficacy (shown in red dots).