Table 3. Stage 2 analysis showed the association of SNPs in (s)ANK1 for T2D development and the levels of HbA1c, Hb and fasting glucose.
| T2D Developmenta | HbA1c (%) adjusted for glucose, sex, ageb | Hb (g/L) adjusted for sex, ageb | Fasting glucose (mmol/L) adjusted for sex, ageb | |
|---|---|---|---|---|
| SNP (Effect/other) | ||||
| rs508419 (C/T) | 1.531 (1.215–1.930)2.85 × 10−4 | 0.069 (0.008)0.115 | 0.005 (0.001)0.898 | −0.015 (0.005)0.696 |
| rs515071 (C/T) | 1.468 (1.199–1.798)1.86 × 10−4 | 0.049 (0.008)0.261 | 0.047 (0.001)0.263 | 0.008 (0.006)0.828 |
| rs516946 (C/T) | 1.495 (1.187–1.882)5.88 × 10−4 | 0.071 (0.007)0.106 | 0.000 (0.001)0.996 | −0.005 (0.005)0.893 |
| CCC | 1.477 (1.203–1.814)1.87 × 10−4 | 1.292 (0.930 ~ 1.794)0.125 | 0.711 (0.491 ~ 1.029)0.069 | 0.817 (0.578–1.154)0.251 |
| rs4737009 (A/G) | − | −0.031 (0.012)0.488 | 0.025 (0.001)0.473 | 0.026 (0.008)0.495 |
| rs6474359 (C/T) | − | −0.001 (0.005)0.978 | −0.059 (0.001)0.161 | − 0.027 (0.004)0.481 |
aData were showed as OR (95% CI) (upper) and p value (lower).
bData were showed as β (SE) (upper) and p value (lower) after adjusted.