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. 2016 Apr 14;8(4):100. doi: 10.3390/v8040100

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Limited inhibitory effects of NIC10, NIC12 and NIC12 derivatives on de novo polymerase activity of rabbit calicivirus RdRps in vitro. The effects of (a) NIC10; (b) NIC12 and the NIC12 derivatives; (c) NIC12-2; (d) NIC12-3; (e) NIC12-4; and (f) NIC-12-5 on the de novo activity of RHDV and RCV RdRps were analysed by monitoring the formation of dsRNA. The chain terminator 3′dGTP (10 µM) was used as a positive control (a,b). RHDV RdRp activity is shown in red, RCV RdRp activity is shown in blue. The results are averages of relative fluorescence levels determined from three independent experiments with triplicate reactions for each measurement point plotted with standard deviations.