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Host shutoff mechanisms in γ-herpesviruses.
| Level of Regulation | Viral Protein | Molecular Activity | Result | Interacting Cellular Proteins |
|---|---|---|---|---|
| Transcription | MHV68 muSOX (through feedback mechanism) | Unknown | Inhibition of transcription initiation | Xrn1 (functional interaction) |
| RNA stability | KSHV SOX, MHV68 muSOX, EBV BGLF5 | RNA endonuclease | Degradation of host and viral mRNAs; nuclear relocalization of PABPC | Unknown |
