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. 2016 Apr 12;8(4):106. doi: 10.3390/toxins8040106

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of cannabinoid antagonists on δ-CNTX-Pn1a antinociception following prostaglandin E₂-induced hyperalgesia. Rats received AM251 (a) or AM630 (b) through intrathecal route 2 h and 45 min after prostaglandin E₂ (PGE₂) injection (2 µg/paw). δ-CNTX-Pn1a, 0.5 μg (0.1 nmol), or saline (control) were intrathecally injected 10 min after the antagonists. Nociceptive threshold was measured 5 min after peptide or saline injection. Vertical bars represent MEAN ± SEM. n = 4 rats per group. Data were analyzed using ANOVA and Bonferroni post-test. p < 0.05 compared to PGE₂ + Saline (*) or PGE₂ + δ-CNTX-Pn1a + Saline (#).