Figure 1.

From mollusks to medicine. Overview of venomics approach for discovery, characterization, and development of therapeutics from Terebridae venom peptides. This strategy begins with a phylogenetic delimitation of venomous terebrid lineages to identify the species that are producing venom to subdue their prey (shown in red); in yellow, identification of teretoxins through omics (genomics, transcriptomics, proteomics); in green, synthesis and structural characterization of teretoxins; in blue, bioactivity assays and identification of molecular targets; and in pink, peptide optimization and development of delivery methods for potential terebrid therapeutics.