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Chemical synthesis of teretoxin Tv1. (a) Automated cycle of solid-phase peptide synthesis using FMOC chemistry; (b) RP-HPLC chromatogram of Tv1 synthesis (linear) and folding reaction. The folded conformation is indicated by the pink diamond and the linear conformation by the yellow diamond. (c) NMR structure of chemically synthesized Tv1. Disulfide bonds are depicted in yellow.
