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. 2016 Apr 19;8(4):117. doi: 10.3390/toxins8040117

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Trojan Horse teretoxin delivery strategy. Schematic overview of peptide drug delivery via virus-like particle (VLP) nanocontainers. The peptide cargo is first encapsulated in the VLP using recombinant biology. The VLP exterior is modified with the cell-penetrating peptide HIV-Tat and norbornene to enable transport to target site and disassembly respectively. The modified VLP nanocontainer is transported to the target site, disassembly is triggered by Grubbs II catalyst and the peptide cargo is released. The modular strategy outlined allows for substitution of alternate conjugates, cargo proteins, and disassembly mechanisms.