Figure 7.

(a) ¹H NMR spectra obtained at various time points following the reaction of APTES with PGMA₅₆–P(HPMA₁₁₅-stat-GlyMA₂₉) after dilution into CD₃OD. The amine reacts with GlyMA as judged by the reduction in the epoxy signal peak at 3.0 ppm compared to the internal standard TMSP. (b) Kinetics of the ring-opening epoxy–amine reaction (blue data set) as judged by the attenuation in the relative integral of the epoxide signal at 3.0 ppm compared to an internal standard by ¹H NMR spectroscopy. Kinetics of worm core cross-linking as judged by the relative attenuation in the integrated pendent methyl group signal at 0.9 ppm assigned to the HPMA residues (red data set) and the relative attenuation in the integrated methyl signal at 1.2 ppm assigned to the methacrylate backbone (green data set) compared to the same internal standard at 0 ppm.