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. Author manuscript; available in PMC: 2017 Feb 4.
Published in final edited form as: Cell Stem Cell. 2015 Dec 10;18(2):262–275. doi: 10.1016/j.stem.2015.11.007

Figure 4. 3D regulatory structures of TADs containing key pluripotency genes.

Figure 4

(A–F) Schematics of 3D structure for TADs containing SMAD3, HMGB3, TBX3, LEFTY1, KLF4 and NANOG in naive hESCs. For each TAD, Hi-C interaction data (Dixon et al., 2015) is shown together with cohesin-associated loop data for TAD-spanning CTCF loops, insulated neighborhood-spanning CTCF loops, enhancer-enhancer loops and enhancer-promoter loops. A subset of CTCF-CTCF loops was selected for display based on a directionality index (Extended Experimental Procedures) and a subset of genes present in these loops is shown for simplicity.

See also Figure S4

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