Table 2.

Predicted homodimers and heterodimers associated with abnormal CFHR proteins in patients with C3 glomerulopathy

Modified CFHR protein	Abnormal homodimers	Abnormal heterodimers
		CFHR1, CFHR3 present	Homozygous ΔCFHR3/1
CFHR112341–5	(CFHR112341–5) × 2	(CFHR112341–5)–CFHR1 (CFHR112341–5)–CFHR2 (CFHR112341–5)–CFHR5	CFHR112341–5)–CFHR2 (CFHR112341–5)–CFHR5
CFHR5121–9	(CFHR5121–9) × 2	(CFHR5121–9)–CFHR1 (CFHR5121–9)–CFHR2 (CFHR5121–9)–CFHR5	(CFHR5121–9)–CFHR2 (CFHR5121–9)–CFHR5
CFHR212–CFHR5	(CFHR212–CFHR5) × 2	(CFHR212–CFHR5)–CFHR1 (CFHR212–CFHR5)–CFHR2 (CFHR212–CFHR5)–CFHR5	(CFHR212–CFHR5)–CFHR2 (CFHR212–CFHR5)–CFHR5
CFHR312–CFHR1	(CFHR312–CFHR1) × 2	(CFHR312–CFHR1)–CFHR1 (CFHR312–CFHR1)–CFHR2 (CFHR312–CFHR1)–CFHR5	(CFHR312–CFHR1)–CFHR2 (CFHR312–CFHR1)–CFHR5