Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 27;17:309. doi: 10.1186/s12864-016-2620-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Riccardi et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 4 — Lineage tracing of Sox2-positive supporting cells after miR-210 overexpression in organ of Corti explants. a Lineage tracing: scheme showing individual mouse lines with modified Sox2 and Rosa26 gene loci for CreERT2 and conditional EGFP expression, respectively. EGFP expression is activated after crossing of both mouse lines and Tamoxifen injection leading to Sox2-Cre-mediated excision of a floxed Stop-cassette which facilitates constitutive EGFP expression in Sox2 expressing cells and cells derived thereof (Sox2 lineage). b Organ of Corti explants of Sox2CreERT2/R26EGFP double transgenic offspring 4 days after Tamoxifen administration. c Organ of Corti explants of Sox2CreERT2/R26EGFP double transgenic offspring 4 days after Tamoxifen administration followed by mir210-Ad5 transduction