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. 2016 Apr 15;17(4):411. doi: 10.3390/ijms17040411

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cross-linked hyaluronic acid-dexamethasone (cHA-Dex) hydrogel exhibited low cytotoxicity compared with Dex only treatment in vitro. The influence of Dex, cHA-Dex (0.2 mg/mL) gel, and cHA-Dex (0.5 mg/mL) gel on the survival of human osteoarthritic chondrocytes was assessed using a methyl thiazolyl tetrazolium (MTT)-based colorimetric assay. Three Dex concentrations were tested, which were 6.6, 13.3, and 26.6 µg/mL. Data were expressed as means ± SD. * represents that the difference was statistically significant (* p < 0.05). n = 3.