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. 2016 Apr 15;17(4):411. doi: 10.3390/ijms17040411

Figure 6.

Figure 6

Intra-articular cross-linked hyaluronic acid-dexamethasone (cHA-Dex) hydrogel injections increased aggrecan (AGG) and decreased type X collagen (COL X) gene expression. (a) The mRNA level of AGG was increased in the cHA-Dex (0.2 mg/mL) gel group compared with the ACLT + saline or cHA only groups (p < 0.05), suggesting a positive impact of the cHA-Dex gel on anabolic metabolism. (b) In contrast, COL X was decreased compared with the ACLT + saline or cHA only groups (p < 0.05). Data were expressed as means ± SD. * represents that the difference was statistically significant, * p < 0.05, ** p < 0.01 and *** p < 0.001. n = 10.