Table 3.
Author and Year | CD Group | Control Group | G vs. A | AG vs. AA | GG vs. AA | HWE p Value | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | AG | GG | AA | AG | GG | OR | 95% CI | OR | 95% CI | OR | 95% CI | ||
Van Heel 2007 UK [18] | 546 | 211 | 20 | 1094 | 307 | 22 | 1.37 | 1.15–1.63 | 1.38 | 1.12–1.69 | 1.82 | 0.99–3.37 | 0.930 |
Hunt 2008 UK [6] | 524 | 179 | 15 | 1190 | 346 | 25 | 1.17 | 0.98–1.40 | 1.17 | 0.95–1.45 | 1.36 | 0.71–2.61 | 0.979 |
Hunt 2008 Ireland [6] | 277 | 125 | 14 | 724 | 216 | 16 | 1.51 | 1.21–1.88 | 1.51 | 1.17–1.96 | 2.29 | 1.10–4.75 | 0.980 |
Hunt 2008 Netherlands [6] | 349 | 144 | 15 | 681 | 193 | 14 | 1.45 | 1.17–1.80 | 1.46 | 1.13–1.87 | 2.09 | 1.00–4.38 | 0.938 |
Romanos 2008 Italy [16] | 427 | 105 | 6 | 521 | 75 | 3 | 1.68 | 1.25–2.26 | 1.71 | 1.24–2.36 | 2.44 | 0.61–9.81 | 0.865 |
Coenen 2009 Netherlands [14] | 548 | 224 | 23 | 1303 | 355 | 24 | 1.50 | 1.27–1.78 | 1.50 | 1.23–1.82 | 2.28 | 1.28–4.07 | 0.974 |
Dubois 2010 UK1 [15] | 515 | 202 | 20 | 2019 | 540 | 36 | 1.47 | 1.25–1.85 | 1.47 | 1.21–1.77 | 2.18 | 1.25–3.79 | 0.987 |
Dubois 2010 UK2 [15] | 1339 | 469 | 41 | 3814 | 1050 | 72 | 1.27 | 1.14–1.42 | 1.27 | 1.12–1.44 | 1.62 | 1.10–2.39 | 0.977 |
Dubois 2010 Finland [15] | 487 | 148 | 11 | 1478 | 332 | 19 | 1.35 | 1.11–1.63 | 1.35 | 1.09–1.68 | 1.76 | 0.83–3.72 | 0.941 |
Dubois 2010 Netherlands [15] | 555 | 226 | 23 | 658 | 176 | 12 | 1.52 | 1.25–1.73 | 1.52 | 1.21–1.91 | 2.27 | 1.12–4.61 | 0.952 |
Dubois 2010 Italy [15] | 392 | 99 | 6 | 473 | 68 | 2 | 1.77 | 1.30–2.41 | 1.76 | 1.25–2.46 | 3.62 | 0.73–18.04 | 0.788 |
Dubois 2010 USA [15] | 720 | 234 | 19 | 432 | 116 | 8 | 1.21 | 0.97–1.51 | 1.21 | 0.94–1.56 | 1.42 | 0.62–3.28 | 0.946 |
Dubois 2010 Hungary [15] | 674 | 265 | 26 | 839 | 214 | 14 | 1.54 | 1.28–1.84 | 1.54 | 1.25–2.45 | 2.31 | 1.20–4.46 | 0.932 |
Dubois 2010 Ireland [15] | 398 | 179 | 20 | 1094 | 336 | 26 | 1.46 | 1.22–1.75 | 1.46 | 1.18–1.81 | 2.11 | 1.17–3.83 | 0.972 |
Dubois 2010 Poland [15] | 390 | 158 | 16 | 538 | 165 | 13 | 1.32 | 1.06–1.64 | 1.32 | 1.02–1.70 | 1.70 | 0.81–3.57 | 0.932 |
Dubois 2010 Spain [15] | 439 | 105 | 6 | 355 | 74 | 4 | 1.14 | 0.85–1.53 | 1.15 | 0.83–1.59 | 1.21 | 0.34–4.33 | 0.947 |
Dubois 2010 Italy [15] | 825 | 175 | 9 | 683 | 116 | 5 | 1.24 | 0.98–1.57 | 1.25 | 0.97–1.61 | 1.49 | 0.50–4.47 | 0.975 |
Dubois 2010 Finland [15] | 200 | 55 | 4 | 514 | 131 | 8 | 1.09 | 0.80–1.50 | 1.08 | 0.76–1.54 | 1.28 | 0.38–4.31 | 0.914 |
Sperandeo 2011 Italy [17] | 526 | 106 | 5 | 610 | 92 | 9 | 1.20 | 0.91–1.57 | 1.34 | 0.99–1.81 | 0.64 | 0.21–1.93 | 0.029 |
Plaza-Izurieta 2011 Spain [7] | 847 | 231 | 16 | 443 | 92 | 5 | 1.31 | 1.03–1.67 | 1.31 | 1.00–1.72 | 1.67 | 0.61–4.60 | 0.926 |
Overall OR | – | – | – | – | – | – | 1.37 | 1.31–1.43 | 1.37 | 1.30–1.44 | 1.82 | 1.55–2.14 | – |
HWE: Hardy–Weinberg equilibrium.