Figure 4.

ERRα bound to Na⁺/K⁺-ATPase (Atp1a) and ENaC promoters in the kidney of the SS rats. (A) CHIP assay showing ERRα binding to the Atp1a and the ENaC promoters; (B) CHIP assay showing the relative binding capacity of the immunoprecipitated ERRα to the ENaC promoter in DS rats; (C) relative binding capacity of immunoprecipitated factor. Data were estimated by $\widehat{2}$ (C_t ^mock − C_t ^specific), and normalized with input, * p < 0.001, compared with SN and SHD groups. The SN group was used as the control.