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Biogenesis of miRNA. Please refer to the main text for details. RNA Pol II: RNA Polymerase II; Pri-miRNA: Primary-miRNA; Pre-miRNA: Precursor-miRNA; DGCR8: DiGeorge syndrome critical region gene 8; Drosha: Ribonuclease Type III; Dicer: RNase III endonuclease; PACT: protein activator of the interferon induced protein kinase; TRBP: TAR RNA binding protein; RISC: RNA induced silencing complex; Ago2: Argonaute 2.
