Table 9.
Predicted neurohormones targets for 71 heart failure related miRNAs.
| miRNA | Targetscan | miRDB | miRanda | ||
|---|---|---|---|---|---|
| Conserved | Poorly Conserved | Gene (Target Score *) | Good mirSVR Score and Conserved | Non-Good mirSVR Score and Conserved | |
| miR-1 | – | AGTR1 | – | AGTR1, EDNRB | AGT, ACE, EDN1, EDNRA |
| miR-100 | – | – | – | – | NPR3 |
| miR-101-3p | – | ACE | – | AGTR2, CALCRL, EDN1, EDNRB, NR3C2 | AGT, CALCRL, EDN1 |
| miR-103a-3p | CRHR2 | AGT, AGTR1, NPPA | – | REN | AGT, CRHR1, UCN2, NR3C2, NPR2, NPPA, EDNRA, EDN1, ATP6AP2, ACE, AGTR2, AGTR1 |
| miR-107 | CRHR1 | AGT, AGTR1, NPPA | – | REN | AGT, AGTR1, AGTR2,ACE, ATP6AP2, EDN1, EDNRA, NPPA, NPR2, NR3C2, UCN2, CRHR1 |
| miR-122 | – | – | – | ATP6AP2, EDN1, NPR3, CRHR1 | ACE, ATP6AP2, EDNRA, CRHR1, CRHR2, NR3C2, CYP11B2 |
| miR-1228-5p | – | – | – | – | – |
| miR-1233-3p | CRHR2 | – | – | – | – |
| miR-124-5p | – | – | – | AGTR1, EDNRB, NR3C2 | ACE, EDN1, NPR1, CYP11B2, NR3C2, CRHR1 |
| miR-1246 | – | – | – | – | – |
| miR-1254 | – | ACE, NPR1, CYP11B2 | NPR3(63) | – | – |
| miR-125a-5p | CRHR2 | ACE, CYP11B2 | – | NPR3, CYP11B2 | – |
| miR-125b-5p | CRHR1 | ACE, CYP11B2 | – | NPR3, CYP11B2 | AGTR2, ACE, EDN1, EDNRA |
| miR-126-3p | – | – | – | – | – |
| miR-129-5p | – | AGT, NPR1, NPR2 | NR3C2(84), AGTR1(76) | EDN1, EDNRA, EDNRB, NPR3, NR3C2 | ACE, CALCRL, ATP6AP2, EDN1, EDNRA, EDNRB, NPR2, NPR3, AGT |
| miR-130a-3p | – | NPR1 | EDN1(69) | ATP6AP2, EDN1, NR3C2 | AGT, ACE, EDN1, EDNRA, NR3C2, CRHR1 |
| miR-133b | – | – | ATP6AP2(54) | ATP6AP2, CRHR1 | |
| miR-139-5p | – | NPPA | – | CALCRL, EDNRB, NPPA, NPR3, NR3C2 | ACE, CALCRL, EDNRA, EDNRB, NR3C2 |
| miR-142-3p | – | - | – | CALCRL, NR3C2 | ACE, CALCRL, EDNRA, EDNRB, NR3C2 |
| miR-142-5p | AGTR2 | AGT, ACE | – | – | – |
| miR-145-5p | – | AGT | – | AGTR2, CALCRL | AGTR2, ACE, ATP6AP2, EDN1, EDNRB, CRHR1 |
| miR-146a-5p | – | CRHR2, NPR1, CRHR2 | – | CALCRL, EDNRB, NPR2, NPR3 | – |
| miR-150-5p | CRHR2 | GRP182, NPR1 | – | ATP6AP2, EDNRB, NPR3 | – |
| miR-17-5p | – | AGTR2, NPR1 | – | AGTR2, ACE, NPR3 | AGTR2, ACE, CALCRL, EDN1, EDNRA, EDNRB, NPR3, NR3C2 |
| miR-181b-5p | – | AGT, AGTR1 | ADM(74), CALCRL(56) | AGTR1, ADM, CALCRL, NPR3, ATP6AP2, EDNRB, NR3C2 | AGT, ACE, EDRNA |
| miR-183-3p | – | AGTR1 | – | – | – |
| miR-185-5p | CRHR2 | ACE, NPR1, CYP11B2 | – | CYP11B2 | – |
| miR-18b-3p | – | CYP11B2 | – | – | – |
| miR-190a | – | – | – | – | – |
| miR-192 | – | – | – | NPR3 | AGTR2, ACE, CALCRL, EDN1, UCN2, CRHR1 |
| miR193b-3p | – | AGT, CYP11B2, CRHR2 | – | EDN1 | – |
| miR-193b-5p | – | NPR1 | – | – | – |
| miR-194-5p | NPPA | – | EDN1(70) | EDN1, NPPA, NPR3 | – |
| miR-195-5p | – | AGT, CYP11B2, CRHR2 | – | AGTR2, NPR2, NPR3 | – |
| miR-199a-5p | – | ACE | – | AGTR2, DNRA, EDNRB, UCN2 | AGTR1, ACE, ATP6AP2, EDN1, EDNRA, CYP11B2, CRHR1, CRHR2 |
| miR-200b-5p | – | AGTR1 | – | – | – |
| miR-208a | AGTR2 | – | – | ATP6AB2, EDNRB | AGTR1, CALCRL, UCN2 |
| miR-21-5p | – | – | NPPB(69) | EDNRB | EDNRA, NPPA, NPPB |
| miR-210-5p | – | NPR1 | – | CRHR2 | NR3C2 |
| miR-211-5p | – | – | NR3C2(86) | CALCRL, ATP6AP2, EDNRA, NPR3, NR3C2, CRHR2 | ATP6AP2, EDN1, EDNRA, CRHR1, CRHR2 |
| miR-214-3p | – | ACE, REN | – | AGTR1, CALCRL, REN, EDN1, EDNRB, CRHR1 | EDN1, EDNRA, NPPA, NPR2, UCN2 |
| miR-22-3p | – | AGT | – | ACE, EDNRA, NPR3, CRHR1 | ACE, NPPA, NPR2, CYP11B2, NR3C2, CRHR1, CRHR2 |
| miR-221-3p | – | ACE | – | NPR3, NR3C2 | ACE, CALCRL, EDNRA, EDNRB, NPR2, NR3C2, CRHR1 |
| miR-23a-3p | – | NPR1 | NPR3(60) | AGTR2, CALCRL, EDNRB | ACE, ADM, CALCRL, EDN1, EDNRA, NR3C2 |
| miR-29a-3p | – | – | – | EDNRB, NPPA, NPR3 | AGTR1, ACE, EDNRB, CYP11B2, UCN2 |
| miR-29b-3p | – | – | – | EDNRB, NPPA, NPR3 | AGTR1, ACE, EDNRB, CYP11B2, UCN2 |
| miR-30a-5p | – | – | EDNRA(54) | EDN1, EDNRA, EDNRB, NPR3 | AGTR1, AGTR2, EDNRA, EDNRB, NR3C2 |
| miR-30b-5p | – | – | EDNRA(54) | AGTR1, EDN1, EDNRA, EDNRB, NPR3 | AGTR2, EDNRA, EDNRB, NR3C2 |
| miR-30c-5p | – | – | EDNRA(54) | AGTR1, EDN1, EDNRA, EDNRB, NPR3 | AGTR2, EDNRA, EDNRB, NR3C2 |
| miR-320a | – | NPPB | – | EDNRA, NPPB, NPR3, NR3C2, EDNRA, NPR3, NR3C2 | – |
| miR-328-3p | – | AGT, CYP11B2 | – | UCN2 | CRHR2 |
| miR-342-3p | – | – | – | UCN2, CRHR2 | – |
| miR-34a-5p | CRHR1 | NPR1 | UCN2(95), CRHR1(54) | AGTR1, EDNRB, NR3C2, UCN2, CRHR1 | AGT, ACE, CALCRL, EDN1, EDNRA, EDNRB |
| miR-375 | – | AGT, GTR1 | – | ATP6AP2 | AGT |
| miR-378a-5p | – | AGTR2, NPR1, CYP11B2 | – | EDN1, CYP11B2, CRHR1 | – |
| miR-423-5p | – | AGT, REN, CRHR2 | CRHR2(56) | – | – |
| miR-454 | – | NPR1 | – | ATP6AP2, EDN1, NPR3, NR3C2 | – |
| miR-494 | – | – | – | AGTR1, END1, EDNRA, EDNRB, NPR3 | – |
| miR-499-5p | – | – | – | CALCRL, ATP6AP2 | – |
| miR-500a-5p | – | AGTR2 | CALCRL(53) | – | – |
| miR-508-5p | – | ACE | – | – | NPR1 |
| miR-532-3p | – | GPR182, CRHR2 | NPR3(64) | – | – |
| miR-545-5p | – | AGTR1, NPPA | – | – | – |
| miR-550a-5p | – | GPR182, NPR1 | – | NPR1 | – |
| miR-622 | – | AGT, NPPA, NPR1 | – | – | – |
| miR-638 | – | CYP11B2 | – | – | – |
| miR-671-5p | – | ACE, CYP11B2, CRHR2 | DN1(82) | – | – |
| miR-675 | – | – | – | – | – |
| miR-7-5p | – | AGT, AGTR1 | – | AGTR1, EDN1, NPR3 | ACE, CALCRL, ATP6AP2, EDN1, EDNRA, CRHR1, CRHR2 |
| miR-92a-3p | – | NPR1 | – | AGTR2, ADM, EDNRB, NR3C2 | AGTR1, CALCRL, EDNRA, EDNRB, NPR2, NR3C2 |
| miR-92b-3p | – | NPR1 | – | AGTR2, ADM, EDNRB, NR3C2 | EDNRA |
AGT, angiotensinogen (serpin peptidase inhibitor, clade A, member 8); AGTR1, angiotensin II receptor type 1; AGTR2, angiotensin II receptor type 2; ACE, angiotensin I converting enzyme (peptidyl-dipeptidase A); ADM, adrenomedullin; CALCRL, calcitonin gene-related peptide type 1 receptor; GPR182, G-protein coupled receptor 182; REN, renin; ATP6AP2, ATPase, H+ transporting, lysosomal accessory protein 2 (renin receptor); EDN1, endothelin 1; EDNRA, endothelin receptor type A; EDNRB, endothelin receptor type B; NPPA, natriuretic peptide A; NPPB, natriuretic peptide B; NPPC, natriuretic peptide C; NPR1, natriuretic peptide receptor A/guanylate cyclase A; NPR2, natriuretic peptide receptor B/guanylate cyclase B; NPR3, natriuretic peptide receptor C/guanylate cyclase C; CYP11B2, cytochrome P450, family 11, subfamily B, polypeptide 2 (aldosterone synthase); NR3C2, nuclear receptor subfamily 3, group C, member 2 (aldosterone receptor, mineralocorticoid receptor); UCN, urocortin; UCN2, urocortin2; CRHR1, corticotropin releasing hormone receptor 1; CRHR2, corticotropin releasing hormone receptor. * miRDB gene target scores represent the predicted scores assigned by the algorithm. The higher the score (>80), the more statistical confidence in the prediction result.