Table 1.
Type of Mutaton and Mutation Site Location | Pearson Correlation Coefficient (R) | y-Intercept | Slope |
---|---|---|---|
Large-to-Small (173) | 0.489 | 0.328 | 0.692 |
ALA-scanning (577) | 0.488 | 0.268 | 0.695 |
COR, SUP (807) | 0.461 | 0.351 | 0.813 |
RIM, SUR, INT (518) | 0.478 | −0.024 | 1.023 |
ALL (1326) | 0.624 (0.716 ±2SD, 0.603 CV) | 1 | −2.31 × 10−5 |
±2SD: within two standard deviations; CV: 5-fold cross validation test. ALA: Alanine residue; COR: core; SUP: support; RIM: rim; SUR: surface; and INT: interior type of mutation site.