Table 3.
WT Residue | Position | MT Residue | Effect | ΔΔΔG(A) | ΔΔΔG(B) | ΔΔΔG(A + B) |
---|---|---|---|---|---|---|
I | 74 | T | Disease | 0.50 | 0.29 | 0.79 |
R | 134 | S | Polymorphism | 0.32 | 0.64 | 0.96 |
C | 135 | R | Disease | 0.48 | 0.01 | 0.48 |
W | 148 | R | Unclassified | 0.13 | 0.74 | 0.88 |
A | 150 | P | Disease | 0.52 | 0.74 | 1.27 |
A | 175 | D | Disease | 0.56 | 0.52 | 1.08 |
C | 178 | R | Disease | 0.46 | 0.00 | 0.46 |
P | 185 | R | Disease | 0.03 | −0.01 | 0.03 |
E | 207 | Q | Polymorphism | 0.35 | 0.15 | 0.49 |
V | 222 | F | Disease | 0.32 | 0.61 | 0.93 |
L | 229 | P | Disease | 0.86 | 0.85 | 1.72 |
L | 257 | P | Disease | 0.80 | 0.69 | 1.49 |
I | 268 | N | Polymorphism | 0.42 | 0.54 | 0.96 |
L | 284 | P | Disease | 0.85 | 0.85 | 1.69 |
R | 304 | Q | Disease | 0.39 | 0.22 | 0.61 |
R | 304 | W | Disease | 0.27 | 0.24 | 0.52 |
N | 335 | K | Disease | -0.12 | 0.00 | −0.12 |
A | 338 | V | Disease | 0.20 | 0.07 | 0.27 |