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. 2016 Apr 13;17(4):553. doi: 10.3390/ijms17040553

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Comparison of niche components in the female germinal stem cell (fGSC) niche in Drosophila and the hematopoietic stem cell (HSC) niche in mouse: (A) The fGSC is a fixed niche, composed of three niche cells (terminal filament, cap cells and escort cells). Only cap cells contact fGSC directly; the rest interact with fGSC indirectly. Only fGSC and not differentiated cytoblasts contact cap cells; (B) The HSC is a complex niche composed of at least 9 different cell types that impact HSC biology. Mesenchymal stromal cells (MSC) are the cells with the most extensive and pervasive contact, but other cell types also contact HSCs.